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Tramadol vs Oxycodone : Which is better for Pain management?

  •  is a semi-synthetic narcotic (opiate) pain medication. It is synthesized from thebaine, a part of the poppy plant.
  • Tramadol is a schedule IV, man-made (synthetic) pain reliever (analgesic). It is not a narcotic medication, and it is not a nonsteroidal anti-inflammatory drug (NSAIDs).
  • Oxycodone is classified as a Schedule II drug by the US Food and Drug Administration (FDA), which means it has a high potential for addition and abuse. In comparison, Tramadol is classified as a Schedule IV drug, which means it has a lower potential for abuse and a lower risk for dependence.
  • Both oxycodone and tramadol are prescribed for the management of acute and chronic moderate to severe pain.
  • Common side effects of oxycodone and tramadol include:
  • Some of the serious side effects and adverse events are different for oxycodone and tramadol. For example, oxycodone should be used cautiously in the elderly, debilitated patients, and in patients with serious lung disease because it can depress (slow) breathing. Some patients who received tramadol had seizures, and it may cause serotonin syndrome when combined with other drugs that increase serotonin.
  • Oxycodone has several drug interactions, and should not be taken with alcoholbarbiturates, muscle relaxants, or benzodiazepines, for example, alprazolam (Xanax). Several other drug interactions occur with oxycodone.
  • Tramadol also has several drug interactions, for example, with MAOIs or monoamine oxidase inhibitors, or SSRIs (selective serotonin inhibitors), for example fluoxetine (Prozac).
  • The safety of oxycodone and tramadol have not been established. Children born to mothers who were taking oxycodone for a prolonged period of time may suffer side effects.
  • Oxycodone is secreted in breast milk in small amounts, so it may cause side effects in the newborn. The safety of tramadol in breastfeeding women has not been established.

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